Ligand-based discovery of coronavirus main protease inhibitors using MACAW molecular embeddingsArticle Published on 2023-12-012022-11-15 Journal: Journal of Enzyme Inhibition and Medicinal Chemist [Category] 치료제, [키워드] antiviral properties binding affinity cells Cheminformatics Compound compounds conducted coronavirus dataset dose-dependent inhibition drug design Drug discovery evaluate half-maximal inhibitory concentration in silico inhibitor inhibitory effect ligand-based drug design M pro Machine learning. machine-learning molecular protease Protease inhibitor screened selected thought Toxicity Virtual screening virus infectivity [DOI] 10.1080/14756366.2022.2132486 PMC 바로가기
India and the COVID-19 vaccine인도와 코로나19 백신Article Published on 2022-12-312022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 변종, [키워드] approval candidate clinical development country COVID-19 vaccine COVID-19 vaccines Critical declined distribution Emergency use ENhance Health Organization highlight India lack Participation provoking public trust Regulatory regulatory system. reported Research SARS-CoV-2 stature thought Vaccine World Health Organization [DOI] 10.1080/21645515.2022.2033541 PMC 바로가기 [Article Type] Article
“COVID toes”: A true viral phenomenon or a diagnosis without a leg to stand on?Review article Published on 2022-12-012022-10-05 Journal: JAAD International [Category] 변종, [키워드] acral lesions acro-ischemia association chilblain-like lesions (CBLL) chilblains coronavirus COVID toes COVID-19 COVID-19 infection cutaneous vasculitis Diagnosis Epstein-Barr virus (EBV) Evidence Factor V Leiden histological Humoral immunity immunological Infection interferon (IFN) lesion lesions lipoprotein A over pandemic Pathogenesis pernio postacute sequelae of COVID-19 (PASC) pseudo-chilblains serological skin of color Support thought Vaccine virus [DOI] 10.1016/j.jdin.2022.06.012 [Article Type] Review article
CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responsesArticle Published on 2022-10-242022-11-15 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] ACE2 activated Activation alleviate Antigen CD169 CD169+ macrophage contribute COVID-19 pathology COVID-19 patients de novo elicited exogenous ACE2 expression expression of SARS-CoV-2 facilitated genomic humans Hyperinflammatory IL-1β IL-6 independent induce Infection innate immune response Macrophage macrophages MDA-5 monocyte myeloid cell Post-mortem primary target cell pro-inflammatory cytokine pro-inflammatory response Remdesivir Replication Restricted RIG-I RNA SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection subgenomic RNA subsequent suppressed the SARS-CoV-2 thought TNFα Treatment viral particle Viral protein Viral RNA [DOI] 10.1371/journal.ppat.1010479 PMC 바로가기
Estimation of R0 for the spread of SARS-CoV-2 in Germany from excess mortalityArticle Published on 2022-10-142022-11-16 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI calculated can be used contagious dataset death deaths determine early phase Effect estimate estimation Europe Germany growth growth factor incidence Infection lockdown measure Mortality much higher much lower office pandemic performed Robert Koch RT-PCR RT-PCR test RT-PCR testing SARS-CoV-2 Spread subject thought used data variant yielding [DOI] 10.1038/s41598-022-22101-7 PMC 바로가기
Severe COVID-19 induces autoantibodies against angiotensin II that correlate with blood pressure dysregulation and disease severityArticle Published on 2022-10-072022-11-15 Journal: Science Advances [Category] COVID19(2023년), SARS, 진단, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 antibody autoantibody Blood blood pressure coronavirus COVID-19 develop disease severity distress domain dysregulation epitope hospitalized patient immune reaction impair induce life-threatening main entry receptor Oxygenation peptide proportion Protein RBD regulate Regulation SARS-CoV-2 spike the SARS-CoV-2 thought thrombosis with COVID-19 [DOI] 10.1126/sciadv.abn3777 PMC 바로가기
Emotions and Topics Expressed on Twitter During the COVID-19 Pandemic in the United Kingdom: Comparative Geolocation and Text Mining AnalysisArticle Published on 2022-10-052022-11-16 Journal: Journal of Medical Internet Research [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Analysis approach can be used change changed Comparative conditions COVID-19 COVID-19 pandemic declined deep learning deep learning-based method dominant emotion emotion detection epidemiological epidemiological situation Express expressing expression geolocation Government Health increase in measure natural language processing negative emotion Neutral omicron optimism outbreak over pandemic platform positive positive attitude Positive emotion proportion public health sentiment analysis social media text text mining the epidemic thought Topic topic modeling. Twitter United Kingdom vaccination variant [DOI] 10.2196/40323 PMC 바로가기
Fate of selected pharmaceuticals in hospital and municipal wastewater effluent: occurrence, removal, and environmental risk assessmentArticle Published on 2022-10-012022-11-15 Journal: Environmental science and pollution research inter [Category] 치료제, [키워드] activated Atenolol Cancer cardiovascular disease caused Concentration condition Conventional Conventional treatment COVID-19 COVID-19 pandemic COVID-19 patient discharge distribution drug drugs evaluated examined high risk highest hospital Hospital wastewater increase in Occurrence organism pandemic Pharmaceuticals Psychiatric Quotient ranged receiving risk Risk assessment risk assessment. risk ratios selected therapy thought Total Treatment was determined β-blocker β-blockers [DOI] 10.1007/s11356-022-21131-y PMC 바로가기
Trends and prevalence of suicide 2017–2021 and its association with COVID-19: Interrupted time series analysis of a national sample of college students in the United StatesShort communication Published on 2022-10-012022-10-05 Journal: Psychiatry research [Category] 진단, [키워드] Analysis analyzed Anxiety association cause COVID-19 COVID-19 infection COVID-19 mitigation death Factors food insecurity ideation impairment Infection Interrupted mental health mind multivariable logistic regression National Odds ratio pandemic performed Prevalence random reduction in Result risk factor severe depression significant decrease significantly Stress Suicide the United State thought trend with COVID-19 [DOI] 10.1016/j.psychres.2022.114796 [Article Type] Short communication
Omicron (BA.1) and sub-variants (BA.1.1, BA.2, and BA.3) of SARS-CoV-2 spike infectivity and pathogenicity: A comparative sequence and structural-based computational assessmentSARS-CoV-2 스파이크 감염성 및 병원성의 오미크론(BA.1) 및 하위 변이체(BA.1.1, BA.2 및 BA.3): 비교 시퀀스 및 구조 기반 계산 평가Article Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 binding acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin BA.1 BA.2 BA.3 BA1.1 bind binding affinity bronchial cells computational tool computational tools contribute contributing to coronavirus COVID-19 Deleterious domain Effectiveness electrostatic expressed Factor hACE2 higher affinity human ACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 hydrogen hydrogen bonds indicate Interaction K417N less lineages Lower respiratory tract lung mutated Mutation mutations N-terminal domain N501Y negative NTD omicron Omicron variant pathogenicity positive predicted Q498 RBD RBM receptor receptors residue residues Salt Bridge SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2. sequence severe acute respiratory syndrome Coronavirus significantly Spike protein Spread surface potential T478K the RBD the spike protein thought Transmission transmission potential variant variants wild-type [DOI] 10.1002/jmv.27927 PMC 바로가기 [Article Type] Article